Esperanza, Cabo San Lucas (Baja Peninsula)
Seclusion factor: Spa suites, Palapa Casitas, have thatched roofs and private infinity-edge hot tubs.
What makes it special: Sip through a tequila tasting class and learn the nuances of agave. The resort stocks more than 100 varieties.
Cost: from $675 per night; 866/311-2226 or esperanzaresort.com